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Also, new insights on the already known acute effect of FFAs as insulin secretagogues 43 have arisen from a recent study in mice treated with a 3-agonist demonstrating insulin secretion in a WAT lipolysis-dependent manner 26 , pointing to an indirect effect of G49 in enhancing insulin secretion through WAT lipolysis that likely boosts the GLP-1R-mediated effect as reflected by the lower insulin secretagogue effect of Fc-GLP1, as well as by the reduced effect of G49 when administered to mice lacking ATGL in adipose tissue

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